Ramesh Mendis is a Sri Lankan all-rounder known for his right-arm off-break bowling and right-handed batting. His rise in Sri Lanka's domestic cricket scene began in March 2018 when he was named to Kandy's squad for the 2017–18 Super Four Provincial Tournament. Later, he joined Dambulla's squad for the 2018 SLC T20 League, further establishing his presence in the domestic circuit.

The 2018-19 season was a breakthrough one for Ramesh, as he became the leading run-scorer for Moors Sports Club in the Premier League Tournament, amassing 612 runs in nine matches. His all-round brilliance also saw him top the bowling charts for his team, claiming 30 wickets in the same tournament. These stellar performances earned him a spot in Dambulla's squad for the 2019 Super Provincial One Day Tournament and a place in Sri Lanka’s squad for the 2019 ACC Emerging Teams Asia Cup in Bangladesh.

Ramesh's career took a giant leap forward in January 2020 when he scored his maiden double century in first-class cricket, an unbeaten 205 runs for Moors Sports Club. He then made history by scoring a remarkable triple century, finishing with 300 not out. His growing reputation was further cemented when he was drafted by Dambulla Viiking for the inaugural Lanka Premier League in October 2020.

Ramesh's international career took a significant turn in January 2021 when he was named a reserve player for Sri Lanka's Test matches against England. The year 2021 turned out to be a memorable one for Ramesh as he made his debut in all three formats.