| # | Player | Mat | Inn | Runs | Highest | Avg | 100s | 50s |
|---|---|---|---|---|---|---|---|---|
| 1 | Quinton de Kock | 92 | 91 | 2,584 | 100 | 31.51 | 1 | 16 |
| 2 | David Miller | 127 | 112 | 2,550 | 106* | 33.55 | 2 | 8 |
| 3 | Reeza Hendricks | 78 | 77 | 2,271 | 117 | 30.28 | 1 | 17 |
| 4 | JP Duminy | 81 | 75 | 1,934 | 96* | 38.68 | - | 11 |
| 5 | AB de Villiers | 78 | 75 | 1,672 | 79* | 26.12 | - | 10 |
| 6 | Faf du Plessis | 47 | 47 | 1,466 | 119 | 36.65 | 1 | 10 |
| 7 | Aiden Markram | 57 | 53 | 1,367 | 70 | 30.37 | - | 9 |
| 8 | Rassie van der Dussen | 50 | 46 | 1,257 | 94* | 33.97 | - | 9 |
| 9 | Hashim Amla | 41 | 41 | 1,158 | 97* | 32.16 | - | 7 |
| 10 | Heinrich Klaasen | 58 | 53 | 1,000 | 81 | 23.25 | - | 5 |
| 11 | Graeme Smith | 33 | 33 | 982 | 89* | 31.67 | - | 5 |
| 12 | Rilee Rossouw | 29 | 27 | 767 | 109 | 34.86 | 2 | 3 |
| 13 | Tristan Stubbs | 35 | 29 | 670 | 76 | 29.13 | - | 2 |
| 14 | Temba Bavuma | 36 | 35 | 670 | 72 | 21.61 | - | 1 |
| 15 | Jacques Kallis | 25 | 23 | 666 | 73 | 35.05 | - | 5 |
| 16 | JA Morkel | 50 | 38 | 572 | 43 | 21.18 | - | - |
| 17 | Farhaan Behardien | 38 | 30 | 518 | 64* | 32.37 | - | 1 |
| 18 | Herschelle Gibbs | 23 | 23 | 400 | 90* | 18.18 | - | 3 |
| 19 | LE Bosman | 14 | 14 | 323 | 94 | 24.84 | - | 3 |
| 20 | MV Boucher | 25 | 21 | 268 | 36* | 17.86 | - | - |
| 21 | RD Rickelton | 13 | 13 | 263 | 76 | 20.23 | - | 1 |
| 22 | Dwaine Pretorius | 30 | 17 | 261 | 77* | 21.75 | - | 1 |
| 23 | Janneman Malan | 11 | 11 | 241 | 55 | 21.90 | - | 1 |
| 24 | RE Levi | 13 | 13 | 236 | 117* | 21.45 | 1 | 1 |
| 25 | MN van Wyk | 8 | 7 | 225 | 114* | 37.50 | 1 | 1 |
| 26 | CA Ingram | 9 | 9 | 210 | 78 | 26.25 | - | 1 |
| 27 | JM Kemp | 8 | 7 | 203 | 89* | 50.75 | - | 1 |
| 28 | Johan Botha | 40 | 20 | 201 | 34 | 18.27 | - | - |
| 29 | JJ Smuts | 13 | 13 | 174 | 45 | 13.38 | - | - |
| 30 | Wayne Parnell | 56 | 23 | 174 | 29* | 17.40 | - | - |
| 31 | Marco Jansen | 17 | 12 | 166 | 54 | 18.44 | - | 1 |
| 32 | Andile Phehlukwayo | 42 | 25 | 166 | 27* | 9.22 | - | - |
| 33 | H Davids | 9 | 9 | 161 | 68 | 17.88 | - | 2 |
| 34 | George Linde | 16 | 12 | 159 | 48 | 14.45 | - | - |
| 35 | Justin Ontong | 14 | 10 | 158 | 48 | 15.80 | - | - |
| 36 | Kagiso Rabada | 65 | 24 | 156 | 22 | 17.33 | - | - |
| 37 | MP Breetzke | 10 | 10 | 151 | 51 | 16.77 | - | 1 |
| 38 | Chris Morris | 23 | 13 | 133 | 55* | 14.77 | - | 1 |
| 39 | Pite van Biljon | 10 | 8 | 125 | 42 | 20.83 | - | - |
| 40 | Robin Peterson | 21 | 12 | 124 | 34 | 15.50 | - | - |
| 41 | Mangaliso Mosehle | 7 | 6 | 105 | 36 | 21.00 | - | - |
| 42 | Willem Mulder | 11 | 8 | 105 | 36 | 17.50 | - | - |
| 43 | Keshav Maharaj | 39 | 15 | 103 | 41 | 11.44 | - | - |
| 44 | David Wiese | 20 | 11 | 92 | 28 | 13.14 | - | - |
| 45 | Shaun Pollock | 12 | 9 | 86 | 36* | 12.28 | - | - |
| 46 | G Coetzee | 10 | 9 | 81 | 23 | 11.57 | - | - |
| 47 | D Ferreira | 6 | 5 | 79 | 48 | 15.80 | - | - |
| 48 | Bjorn Fortuin | 25 | 16 | 76 | 17* | 8.44 | - | - |
| 49 | PE Kruger | 7 | 5 | 72 | 44 | 18.00 | - | - |
| 50 | Christiaan Jonker | 2 | 2 | 57 | 49 | 28.50 | - | - |
| 51 | Roelof van der Merwe | 13 | 6 | 57 | 48 | 19.00 | - | - |
| 52 | Heino Kuhn | 7 | 6 | 49 | 29 | 12.25 | - | - |
| 53 | JJ van der Wath | 8 | 4 | 46 | 21 | 15.33 | - | - |
| 54 | Lungi Ngidi | 43 | 13 | 41 | 13* | 8.20 | - | - |
| 55 | Sisanda Magala | 6 | 3 | 34 | 18* | 34.00 | - | - |
| 56 | Rusty Theron | 9 | 3 | 32 | 31* | 0.00 | - | - |
| 57 | Theunis de Bruyn | 2 | 2 | 26 | 19 | 13.00 | - | - |
| 58 | Rory Kleinveldt | 6 | 3 | 25 | 22 | 25.00 | - | - |
| 59 | KJ Abbott | 21 | 6 | 23 | 9* | 11.50 | - | - |
| 60 | N Peter | 8 | 4 | 22 | 10* | 11.00 | - | - |
| 61 | A Simelane | 5 | 5 | 21 | 7 | 5.25 | - | - |
| 62 | Morne Morkel | 41 | 7 | 21 | 8* | 10.50 | - | - |
| 63 | Dale Steyn | 47 | 12 | 21 | 5* | 3.50 | - | - |
| 64 | Aaron Phangiso | 16 | 3 | 19 | 13 | 6.33 | - | - |
| 65 | Imran Tahir | 35 | 4 | 19 | 9* | 19.00 | - | - |
| 66 | Junior Dala | 10 | 4 | 19 | 12* | 19.00 | - | - |
| 67 | Beuran Hendricks | 19 | 5 | 18 | 12* | 6.00 | - | - |
| 68 | Anrich Nortje | 42 | 12 | 17 | 4* | 2.83 | - | - |
| 69 | WJ Lubbe | 2 | 2 | 16 | 12 | 8.00 | - | - |
| 70 | KT Maphaka | 5 | 3 | 16 | 12* | 0.00 | - | - |
| 71 | GL Cloete | 2 | 2 | 15 | 13 | 7.50 | - | - |
| 72 | VB van Jaarsveld | 3 | 3 | 15 | 12 | 5.00 | - | - |
| 73 | Alviro Petersen | 2 | 2 | 14 | 8 | 7.00 | - | - |
| 74 | Vernon Philander | 7 | 4 | 14 | 6 | 3.50 | - | - |
| 75 | AJ Hall | 2 | 1 | 11 | 11 | 11.00 | - | - |